Variation in Striatal Dopamine-Related Neurophysiology Supports Age-Related Differences in GABA and Glutamate Through Human Adolescence
Ashley Parr, Maria Perica, Finnegan Calabro, Brenden Tervo-Clemmens, William Foran, Victor Yushmanov, Hoby Hetherington, Beatriz Luna
Abstract
Recent research has identified changes in prefrontal cortex (PFC) glutamate (Glu), gamma-aminobutyric acid (GABA), and GABA/Glu balance in adolescence (Perica et al., 2022), potentially reflecting critical period plasticity that supports the development of PFC-dependent cognitive functions. The mechanisms mediating this process remain unknown. Emerging evidence implicates dopamine (DA) in regulating changes in E/I throughout adolescence (Reynolds and Flores, 2021); here, we assess the role of striatal tissue iron, reflecting DA-related neurophysiology, in supporting changes in PFC Glu and GABA during adolescence.
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Brain Mechanisms R01 (7T)
7T Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy Imaging
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Time-averaged T2*