=== Variation in Striatal Dopamine-Related Neurophysiology Supports Age-Related Differences in GABA and Glutamate Through Human Adolescence=== 
Ashley Parr, Maria Perica, Finnegan Calabro, Brenden Tervo-Clemmens, William Foran, Victor Yushmanov, Hoby Hetherington, Beatriz Luna

**Abstract** \\
Recent research has identified changes in prefrontal cortex (PFC) glutamate (Glu), gamma-aminobutyric acid (GABA), and GABA/Glu balance in adolescence (Perica et al., 2022), potentially reflecting critical period plasticity that supports the development of PFC-dependent cognitive functions. The mechanisms mediating this process remain unknown. Emerging evidence implicates dopamine (DA) in regulating changes in E/I throughout adolescence (Reynolds and Flores, 2021); here, we assess the role of striatal tissue iron, reflecting DA-related neurophysiology, in supporting changes in PFC Glu and GABA during adolescence.

[[https://www.biologicalpsychiatryjournal.com/article/S0006-3223(23)00181-6/fulltext |Variation in Striatal Dopamine-Related Neurophysiology Supports Age-Related Differences in GABA and Glutamate Through Human Adolescence - SOBP SPEAKER ABSTRACT 2023]]

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